$48 to $250,000.

"How much does longevity medicine cost?" has no single answer — it spans four orders of magnitude. Here's the 2026 spread on a log scale, from a $4-a-month generic to a quarter-million-dollar week at a Swiss clinic. The pattern worth noticing: the cheap end is also the well-evidenced end.

The 2026 spread

• Metformin — ~$4/mo. Among the best-studied interventions here.
• Rapamycin — ~$77/mo compounded. Best animal-longevity data of any drug.
• Full-body MRI — ~$2,499 (Prenuvo). Measure before you treat.
• Stem cells, Panama — $20,000–$50,000 a course, outside FDA jurisdiction.
• Therapeutic plasma exchange — up to $60,000 a course.
• A week at a Swiss longevity residence — $250,000 and up.

Spending more rarely buys more proof. The interventions with the strongest human evidence sit at the cheap end of this ladder; the frontier — real, and worth watching — sits at the expensive end, where the evidence is thinnest.