Longevity Treatments, Compared
Every major longevity intervention ranked by evidence, with real costs and how to access it.
The longevity interventions people actually ask about — ranked by how strong the evidence is today, with real monthly costs and how you access each. We separate what you can do now from what's still frontier science.
| Treatment | Evidence | Typical cost | How to access | Regulatory |
|---|---|---|---|---|
| GLP-1 Agonists available now | Strong Human RCTs tier 5 | $150–$1,350/month | Widely prescribed by PCPs, endocrinologists, weight management clinics. Branded and compounded available. | approved |
| Hormone Optimization available now | Early Human Data tier 4 | $30–$4,700/month | TRT/BHRT: prescription, widely available. HGH: illegal in US for anti-aging (legal only for diagnosed deficiency). | approved_other_indication |
| Rapamycin available now | Strong Animal + Observational tier 3 | $77–$290/month | Prescription required (off-label). 5-10 mg once weekly. Baseline bloodwork and periodic monitoring. | approved_other_indication |
| Therapeutic Plasma Exchange available now | Strong Animal + Observational tier 3 | $5,000–$60,000/course | Specialized clinics. FDA-approved for autoimmune conditions; longevity use is off-label. Requires medical supervision. Typical course: 3-6 sessions. | approved_other_indication |
| Metformin available now | Strong Animal + Observational tier 3 | $4–$20/month | Any doctor can prescribe off-label. Available at any pharmacy. Extended-release version better tolerated. | approved_other_indication |
| Senolytics (Dasatinib + Quercetin) available now | Strong Animal + Observational tier 3 | $65–$2,000/course | Dasatinib requires prescription (off-label). Quercetin OTC. Typical: 100mg dasatinib + 1000-1250mg quercetin × 2-3 consecutive days, monthly or quarterly. | approved_other_indication |
| NAD+ Infusions and Precursors available now | Preclinical + Mechanistic tier 2 | $30–$1,500/varies | IV NAD+ at wellness clinics nationwide (no prescription). Oral NMN/NR over-the-counter. NAD+ patches via telehealth. | supplement_or_off_label |
| Peptide Therapies available now | Preclinical + Mechanistic tier 2 | $100–$2,000/month | REGULATORY WARNING: FDA classified BPC-157 as Category 2 (safety concerns) in 2024-2025, effectively banning compounding. Many peptides previously available are now legally restricted. Thymosin Alpha-1 still available through some compounding pharmacies. | restricted_2024 |
| Hyperbaric Oxygen Therapy available now | Preclinical + Mechanistic tier 2 | $100–$45,000/varies | HBOT clinics nationwide. FDA-approved for 13 conditions (not anti-aging). Clinical-grade (2.0+ ATA) differs significantly from consumer 'soft shell' chambers. | approved_other_indication |
| Exosome Therapy available now | Early/Speculative tier 1 | $2,000–$18,000/course | FDA WARNING: No exosome products approved for any therapeutic use. Clinics offering this operate outside FDA-approved indications. Patients hospitalized in Nebraska from contaminated products. | warning_letters_issued |
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Prices are list prices gathered from public sources for the May 2026 edition and change often; confirm directly with the provider. 2100 may earn a referral fee from some at-home testing partners at no cost to you — it never changes who we recommend.