Longevity Value Index
Longevity interventions ranked by evidence per dollar — where your money buys the most proven benefit.
Every longevity intervention costs money and carries a different weight of evidence. This ranks them by evidence per dollar: the strength of the human/animal evidence divided by what a year actually costs. It's a blunt instrument on purpose — a high score means you're paying little for something the science backs; a low score means you're paying a lot for something still early. We annualize every price to make a $8/month generic and a $18,000 course comparable, and we skip interventions whose cost is too variable to rank honestly.
| Intervention | Evidence | Annualized cost | Value score |
|---|---|---|---|
| 1. Metformin available now | Strong Animal + Observational tier 3/5 | $144/yr $4–$20/month | 1.39 |
| 2. GLP-1 Agonists available now | Strong Human RCTs tier 5/5 | $9,000/yr $150–$1,350/month | 1.26 |
| 3. Senolytics (Dasatinib + Quercetin) available now | Strong Animal + Observational tier 3/5 | $1,032/yr $65–$2,000/course | 1.00 |
| 4. Hormone Optimization available now | Early Human Data tier 4/5 | $28,380/yr $30–$4,700/month | 0.90 |
| 5. Rapamycin available now | Strong Animal + Observational tier 3/5 | $2,202/yr $77–$290/month | 0.90 |
| 6. Therapeutic Plasma Exchange available now | Strong Animal + Observational tier 3/5 | $32,500/yr $5,000–$60,000/course | 0.66 |
| 7. Peptide Therapies available now | Preclinical + Mechanistic tier 2/5 | $12,600/yr $100–$2,000/month | 0.49 |
| 8. Exosome Therapy available now | Early/Speculative tier 1/5 | $10,000/yr $2,000–$18,000/course | 0.25 |
Score = evidence tier (1 speculative → 5 strong human RCTs) ÷ log₁₀(annual cost). Cost is the midpoint of published price bands, not a quote for you.
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